[Peptides prevent the forming of secretory phenotype of chondrocytes associated with the aging.]

Myakisheva SN, Linkova NS, Kozhevnikova EO, Polyakova VO, Ryzhak GA · Advances in Gerontology (Uspekhi Gerontologii)

Senescent chondrocytes showed raised p16, p21, p53, TNF-alpha and IL-1-alpha and lowered Sirt1; both peptides moved those markers back toward the young-cell pattern. This is the only indexed study of either substance in chondrocytes themselves.

Population

Human chondrocyte cultures showing the senescence-associated secretory phenotype

Intervention

AED tripeptide (Cartalax) and the cartilage polypeptide complex (CPC, the Sigumir substance)

Comparator

Untreated senescent chondrocytes

Limitations

Institute-authored; Russian-language institute-linked journal; secretory-marker readouts only, with no matrix-synthesis or mechanical endpoint; no numbers in the indexed abstract.