Chondrocytes secretory phenotype associated with aging: role in the pathogenesis of osteoarthritis and prospects for peptide bioregulation

Myakisheva SN, Linkova NS, Kozhevnikova EO, et al. · Advances in Gerontology (Uspekhi Gerontologii)

Reviews the senescence-associated secretory phenotype of chondrocytes as a target in osteoarthritis — falling sirtuin synthesis, disrupted matrix remodelling and rising cytokine production — and asserts that Sigumir and the AED tripeptide (Cartalax) showed high efficacy in animal osteoarthritis models and in oral use by older patients with the disease, citing institute-affiliated sources rather than independent trials. It is also the clearest published statement that the two are related substances: it says the AED tripeptide was found inside the cartilage polypeptide complex by matrix-assisted laser desorption ionisation and ultra-performance liquid chromatography mass spectrometry, work it attributes to the Institute of Toxicology of Russia's FMBA, and it names that complex as Sigumir.

Population

Narrative review of chondrocyte aging and Khavinson peptide claims

Intervention

n/a

Comparator

n/a

Limitations

Authors from the originating institute reviewing their own programme, with the efficacy claims asserted rather than appraised and the human data behind them not independently indexed. It gives the complex's peptides as 75 to 10,000 Da, where the mass-spectrometry analysis this site's composition figure rests on gives 75 to 846 Da; the two numbers are not reconciled anywhere.