The Potential Benefic Effect of Nicotinamide Riboside in Treating a Murine Model of Monoiodoacetate-Induced Knee Osteoarthritis

Gherghina FL, Mîndrilă I, Buteică SA, et al. · Journal of Clinical Medicine

The nearest thing to an oral NAD+-precursor joint trial that exists, and it is in rats: NR lowered cartilage-damage (Mankin) scores versus untreated OA and reduced oxidative-stress markers — performing about the same as hydrolyzed collagen at an identical dose, while TNF-α fell more with collagen than with NR.

Population

Wistar rats with monoiodoacetate-induced knee OA, 5 per group

Intervention

Oral nicotinamide riboside 300 mg/kg/day by gavage for 21 days

Comparator

Untreated OA rats; hydrolyzed collagen 300 mg/kg/day; sham

Limitations

Five animals per group; chemically induced OA is a crude model; NR is a different precursor from NMN with different pharmacology. Full text read.