Hyaluronan and chondroitin sulfate in chicken-vegetable bone broth delay osteoporosis progression

Seki Y, Ohkuma RC, Miyakawa Y, Karakida T, Yamamoto R, Yamakoshi Y · Journal of Food Science

The broth fraction containing both hyaluronan and chondroitin sulfate maximally inhibited osteoclast differentiation and downregulated its marker genes; both whole broth and that fraction raised bone mineral density and bone volume/tissue volume on micro-CT versus ovariectomized controls. The first study to identify specific glycosaminoglycans in bone stock as the active constituents.

Population

Ovariectomized rat osteoporosis model, plus RAW264 mouse macrophage osteoclast-differentiation assays

Intervention

Whole chicken-vegetable bone broth, or the ion-exchange fraction containing hyaluronan and chondroitin sulfate

Comparator

Ovariectomized controls and sham-operated animals

Limitations

Rat model with a bone rather than cartilage endpoint. The composition figures are for a purified 48 mg fraction, so the study gives no concentration of hyaluronan or chondroitin per serving of the original broth, and no molecular weights.