A Greater Platelet Dose May Yield Better Clinical Outcomes for Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Systematic Review

Berrigan WA, et al. · Arthroscopy

PRP arms with positive trials averaged ~5.5 billion platelets vs ~2.3 billion in non-positive trials (P<.01); the same pattern held at 12 months. Study-level (ecological) association, not a randomized dose comparison.

Population

29 RCTs of PRP for knee OA (31 PRP treatment arms) with >=6-month outcomes

Intervention

PRP arms grouped by absolute platelet dose

Comparator

Trial-level positive vs non-positive outcome

Limitations

Ecological analysis across heterogeneous trials; platelet dose often estimated; one author discloses industry relationships (Vericel, AlloSource).