Intermediate-Term Clinical Outcomes of High-Density Autologous Chondrocyte Implantation in Patients with Concomitant Anterior Cruciate Ligament Reconstruction and Focal Chondral Lesions

Guillén-Vicente I, López-Alcorocho JM, Guillén-Vicente M, et al. · Cartilage

At 24 months both groups improved substantially (VAS about 8 to about 2; IKDC about 37 to about 75) with 71-90% returning to pre-injury activity; concurrent ACL reconstruction did not worsen results.

Population

48 patients with focal chondral lesions, 24 with concomitant ACL reconstruction and 24 without (CEMTRO, Madrid)

Intervention

High-density ACI (with or without ACL reconstruction)

Comparator

HD-ACI without ACL reconstruction (internal comparison)

Limitations

Small non-randomized comparison, single center, same developing group; 2-year horizon.