Comparative Pharmacokinetics of Curcuminoids from Water-Dispersible Turmeric Extract Against a Curcuminoids-Piperine Combination: An Open-Label, Randomized, Balanced, 2-Treatment, 2-Sequence, 2-Period Crossover Study

Thanawala S, Shah R, Doyle L, Upadhyay V · Alternative Therapies in Health and Medicine

A direct test of the piperine combination against a modern formulation. Total-curcuminoid Cmax was 74.56 ng/mL for the water-dispersible extract against 22.75 ng/mL for the curcuminoid-piperine capsules, and AUC0-t was 419.00 against 359.86 h·ng/mL — equivalent exposure from a tenth of the actives.

Population

Healthy adult males, fasting crossover

Intervention

Water-dispersible turmeric extract WDTE60N, 250 mg once daily

Comparator

Turmeric extract capsules with 500 mg curcuminoids plus 5 mg piperine, taken three times daily (1500 mg curcuminoids total)

Limitations

Open-label, n=16, single day, and run by the test product's manufacturer (Nutriventia), which is the party the comparison favours. Total curcuminoids are measured after deconjugation.