The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6

Bian Y, Deng M, Liu J, Li J, Zhang Q, Wang Z, Liao L, Miao J, Li R, Zhou X, Hou G · Redox Biology

Attenuated lung inflammation and fibrosis without significant systemic toxicity, by binding peroxiredoxin 6 and reducing crystalline-silica-induced oxidative stress in alveolar macrophages.

Population

Experimental silicosis mouse model and RAW264.7 alveolar macrophages

Intervention

GHK-Cu

Comparator

Untreated silica-exposed animals

Limitations

Lung endpoint. The systemic-toxicity statement is an observation within a rodent efficacy study, not a toxicology programme.