Effect of caffeine intake on self-reported and genetic prediction of osteoarthritis: an epidemiological study and Mendelian randomization analysis

Ji Z, Shen Y, Chen D, Liu Z, Dai J, Dai B, Deng W · Frontiers in Nutrition

Runs the observational and the genetic analysis side by side in one paper — the design that makes the coffee literature legible, because the two approaches in this topic have kept disagreeing.

Population

An observational epidemiological sample plus Mendelian randomization on caffeine intake and osteoarthritis

Intervention

Caffeine intake, measured and genetically predicted

Comparator

Lower intake

Limitations

Self-reported intake in the observational arm and the usual instrument limitations in the genetic arm.