Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials

Zhang J, Poon ET, Wong SH · Critical Reviews in Food Science and Nutrition

NMN significantly raised blood NAD+, but most clinically relevant outcomes did not differ from control. Risk-of-bias assessment flagged concerns in seven trials and high risk in five, and the authors concluded that 'an exaggeration of the benefits of NMN supplementation may exist in the field'.

Population

513 adults across 12 randomised trials

Intervention

Oral NMN

Comparator

Placebo or control

Limitations

Heterogeneous doses and durations; the underlying trials are small and largely manufacturer-linked, which the risk-of-bias findings reflect.