Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Wang JP, Wang L, Wang T, Zhang YD, Zhou AJ, Wang ZP · Current Pharmaceutical Biotechnology

The positive counterweight in this literature: pooled gait speed improved (SMD 0.34, 95% CI 0.03 to 0.66, p=0.033) and ALT fell (SMD -0.29, 95% CI -0.55 to -0.03, p=0.028). Subgroup analysis found the lower doses had the larger effect on insulin resistance.

Population

412 middle-aged and elderly participants across 9 randomised trials

Intervention

Oral NMN

Comparator

Placebo

Limitations

Nine small trials, several manufacturer-funded, with the gait-speed confidence interval nearly touching zero. Pools studies whose own primary endpoints were often null.