Two Members of Vitamin-K-Dependent Proteins, Gla-Rich Protein (GRP) and Matrix Gla Protein (MGP), as Possible New Players in the Molecular Mechanism of Osteoarthritis

Kurtuluş B, Atilgan N, Yilmaz M, Dokuyucu R · Journal of Clinical Medicine

Puts a second vitamin-K-dependent protein beside matrix Gla protein. Gla-rich protein is the most γ-carboxylated protein known, is abundant in cartilage, and acts as a calcification inhibitor — so the pathway that vitamin K switches on in a joint has more than one arm to it.

Population

The vitamin-K-dependent protein literature in osteoarthritis

Intervention

Not applicable

Comparator

Not applicable

Limitations

Narrative review of mechanism; no clinical data of its own.