The Effect of Platelet Dose on Outcomes after Platelet Rich Plasma Injections for Musculoskeletal Conditions: A Systematic Review and Meta-Analysis

Berrigan W, et al. · Current Reviews in Musculoskeletal Medicine

In knee OA, doses above roughly 10 billion platelets were associated with more favorable outcomes, more pronounced for function than pain. Supports a dose-response hypothesis but not derived from randomized dose-ranging trials.

Population

PRP trials across musculoskeletal conditions with reported platelet dose

Intervention

Higher platelet dose PRP

Comparator

Lower platelet dose PRP

Limitations

Between-study comparison with heterogeneous preparations and indications; no RCT directly randomizing platelet dose in knee OA yet.