Targeting PAR2-mediated inflammation in osteoarthritis: a comprehensive in vitro evaluation of oleocanthal's potential as a functional food intervention for chondrocyte protection and anti-inflammatory effects

Patnaik R, Varghese R, Jannati S, Naidoo N, Banerjee Y · BMC Musculoskeletal Disorders

Places oleocanthal on protease-activated receptor 2, a route into cartilage inflammation distinct from the cyclooxygenase story it is known for, with protection of chondrocytes and suppression of inflammatory signalling.

Population

Chondrocytes under inflammatory stimulation

Intervention

Oleocanthal

Comparator

Stimulated cells without oleocanthal

Limitations

Cell culture at investigator-chosen concentrations; no animal or human arm.