Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials

Chen F, Zhou D, Kong AP, Yim NT, Dai S, Chen YN · Current Diabetes Reports

NULL across the board: no significant effect of NMN on fasting glucose, fasting insulin, HbA1c, HOMA-IR or any lipid fraction.

Population

342 middle-aged and older adults across 8 randomised trials, mainly non-diabetic

Intervention

NMN 250-2,000 mg/day for 14 days to 12 weeks

Comparator

Placebo

Limitations

Eight small trials in mostly healthy adults — the populations least likely to show metabolic improvement. Short durations.