Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle from Its Attachments for Muscle-to-Bone Reattachment in Rats

Matek D, Matek I, Staresinic E, Seiwerth S, Sikiric P, et al. · Pharmaceutics

Oral therapy produced reattachment on ultrasound, MRI, biomechanical and gait measures; by three months reattachment fibres could be traced into newly formed cortical bone at the surface, with muscle fibres oriented parallel to and in contact with the bone.

Population

Rats with complete (rectus) and partial (vastus) quadriceps muscle-to-bone detachment, followed to 90 days

Intervention

BPC 157 10 µg/kg/day or 10 ng/kg/day per-orally

Comparator

Untreated detachment, which showed permanent knee flexure and impaired walking

Limitations

Originating network; microscopy is reported as blinded but the functional, ultrasound and MRI assessments are not, and imaging and histology carry the claim rather than a load-to-failure comparison. University of Zagreb grant.