Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective

Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR · BioImpacts

Concludes GHK can be considered an anti-wrinkle ingredient on cellular studies, but reports a 'surprising absence of clinical studies' using GHK-Cu or palmitoyl-GHK despite their wide presence in cosmetic products, alongside insufficient published data on skin permeability, effectiveness and physicochemical stability.

Population

Review of GHK, GHK-Cu and palmitoyl-GHK for topical anti-wrinkle use

Intervention

n/a

Comparator

n/a

Limitations

Narrative review from a drug-delivery group; its value here is the negative observation about the clinical base under the cosmetic claims.