Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties

Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł · International Journal of Molecular Sciences

The only review of this peptide series written entirely outside the originating institute — by pharmacy and geriatrics groups in Warsaw and Bydgoszcz, with no external funding and no declared conflict. It accepts that geroprotective and neuroendocrine effects have been reported, and concludes that the mechanism remains unclear and that physico-chemical and structural work on the peptide is very limited.

Population

Twenty-five years of in-vitro, in-vivo, in-silico and clinical work on the AEDG tetrapeptide

Intervention

n/a

Comparator

n/a

Limitations

Narrative review with no protocol or risk-of-bias appraisal; it covers AEDG rather than the AED tripeptide, and contains no cartilage or osteoarthritis content at all; full text read via PMC11943447.