Efficacy of intra-articular platelet-rich plasma compared with placebo in knee osteoarthritis: A systematic review and meta-analysis

Auroux M, et al. · Joint Bone Spine

Small pain benefit over placebo at 3 months (VAS MD -1.1) and 6 months (MD -2.0) that disappears by 12 months; WOMAC favored PRP only at 3 months. Authors call the clinical relevance debatable.

Population

11 placebo-controlled RCTs (849 PRP, 767 saline placebo) in knee OA

Intervention

Intra-articular PRP

Comparator

Saline placebo

Limitations

Heterogeneous PRP preparations and doses pooled; effect sizes small and short-lived.