Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM · HSS Journal

Thirty-six studies met inclusion: 35 preclinical and 1 clinical. Preclinical models improved on functional, structural and biomechanical measures in muscle, tendon, ligament and bone. The single clinical study — retrospective intra-articular injection for chronic knee pain — is summarised as 7 of 12 patients reporting relief beyond six months. The reviewers found no clinical safety data at all.

Population

PubMed, Cochrane and Embase to 3 June 2024; 544 records screened in three phases by two reviewers

Intervention

n/a

Comparator

n/a

Limitations

Level IV and V inputs only, so the review cannot rise above them; its reading of the knee case series (7 of 12 sustained past six months) is narrower than the source's own headline figure, and it does not formally appraise risk of bias in the animal literature.