Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a randomised controlled trial

Yuenyongviwat V, Anusitviwat C, Tuntarattanapong P, Hongnaparak T, Iamthanaporn K · Scientific Reports

Null on every endpoint. Both groups improved significantly over time, but there were no between-group differences in pain intensity, KOOS function, rescue medication use, or patient satisfaction. The authors state their motivation explicitly: previous trials were 'most being industry-sponsored, which raises potential bias concerns'.

Population

Patients with knee osteoarthritis, Prince of Songkla University, Thailand

Intervention

Tablets containing hydrolysed collagen plus undenatured type II collagen, 12 weeks

Comparator

Placebo

Limitations

Modest sample (n=68) and 12 weeks may be short for a structural effect; tests a combination product, so it cannot isolate which component failed. Competing interests: none declared — this is one of the few fully independent trials in the field.