Microfragmented Adipose Tissue as an Alternative to Platelet-Rich Plasma for Intra-articular Injection in Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Park YB, et al. · The American Journal of Sports Medicine

MFAT and PRP produced comparable pain and function improvements through 12-24 months, both typically reaching MCID; MFAT held a small statistical edge at 6 months only.

Population

6 RCTs comparing MFAT and PRP in knee OA, follow-up to 24 months

Intervention

Intra-articular MFAT

Comparator

Intra-articular PRP

Limitations

Small trial pool; no placebo-controlled pooling; heterogeneous MFAT processing.