Altered nicotinamide adenine dinucleotide metabolism drives cartilage degeneration and osteoarthritis

Wu X, et al. · Clinical and Translational Medicine

NAD+ was depleted in OA cartilage; restoring it with NAD+ precursors (including NMN) or NMNAT1 overexpression suppressed cartilage disruption and matrix-degrading changes in rodent OA models.

Population

Human OA cartilage tissue plus ageing and post-traumatic OA mouse/rat models and cultured chondrocytes

Intervention

NAD+ precursors (NMN and nicotinamide riboside); NMNAT1 overexpression; PARP14 knockdown

Comparator

Untreated OA animals/cells

Limitations

Rodent and in-vitro efficacy only; doses and routes not comparable to human oral supplementation; very recent, not independently replicated.