NMN-primed exosomes derived from infrapatellar fat pad mesenchymal stem cells exert synergistic anti-inflammatory and cartilage-protective effects via MERTK pathway activation in knee osteoarthritis

Chen KT, Huang CC, Yadav VK, et al. · International Journal of Pharmaceutics

A delivery technology, not oral NMN: exosomes from NMN-primed fat-pad stem cells, injected into the joint, preserved cartilage architecture and reduced inflammatory and matrix-degrading markers in a mouse OA model.

Population

IL-1β-stimulated human chondrocytes and a papain-induced mouse knee-OA model

Intervention

Intra-articular exosomes harvested from NMN-primed infrapatellar-fat-pad mesenchymal stem cells

Comparator

Untreated OA mice/cells

Limitations

Intra-articular nanotherapeutic in mice — says nothing about swallowing NMN. Record from the abstract; the primed-vs-unprimed exosome comparison is not recorded here.