Additional Benefits of Creatine Supplementation with Physical Therapy and Resistance Exercise in Knee Osteoarthritis: A Randomized Controlled Trial

Osama M, et al. · Journal of Clinical Medicine

Creatine added to physical therapy improved pain (VAS, P=0.001), KOOS scores, isometric strength and fall-risk measures more than physical therapy alone over 4 weeks.

Population

Adults 40-70 with knee OA up to Kellgren-Lawrence grade III (20 per group)

Intervention

Creatine supplementation plus physical therapy (heat, electrotherapy, manual therapy, resistance exercise) for 4 weeks

Comparator

Maltodextrin placebo plus identical physical therapy

Limitations

Small (n=40) and very short (4 weeks); multiple co-interventions; effect durability unknown; recent single-centre trial not yet replicated.