Effects of pentosan polysulfate sodium on joint structure and function out to six months in naturally-occurring canine osteoarthritis

Stapledon CJM, Krishnan R, Peat RA, et al. · PLoS One

Sustained owner-scored pain reduction, gait-symmetry normalization, and increased total cartilage volume on imaging at 26 weeks in the PPS group.

Population

20 companion dogs with naturally occurring OA (14 PPS, 6 placebo)

Intervention

PPS 3 mg/kg subcutaneous weekly for 6 weeks, followed 26 weeks

Comparator

Placebo

Limitations

Sponsor-run (Paradigm authors); tiny unbalanced groups; canine OA is a model, not human evidence.