Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration

Yu J, Hou M, Deng Y, et al. · Aging Cell

Supplying the precursor while blocking the drain: oral NMN plus apigenin in aged mice preserved NAD+, reduced cartilage-damage (OARSI) scores and hyaline-cartilage loss, and improved bone and muscle measures, with the mechanism mapped through the NAD+-dependent mitochondrial deacetylase SIRT3.

Population

Aged (20-month) mice and musculoskeletal precursor cells; SIRT3-knockout mice for mechanism

Intervention

Oral NMN plus the CD38 inhibitor apigenin (the 'N+A' regimen)

Comparator

Untreated aged mice

Limitations

About 5 animals per readout; not independently replicated; NMN-plus-apigenin is not the NMN-plus-resveratrol pairing consumers actually use. Full text read.