Glycyl-L-histidyl-L-lysine-Cu2(+) (GHK-Cu) Attenuates CuSO(4) or LPS induced-inflammation in Zebrafish larvae model

Hu J, Zhang C, Wang F · European Journal of Pharmacology

Reduced neutrophil and macrophage migration, lowered tnf-a, il-1β and il6 and raised il-10, cut nitric oxide and reactive oxygen species and raised superoxide dismutase, with downregulation of the JAK1 pathway.

Population

Zebrafish larvae with copper-sulfate- or LPS-induced acute inflammation

Intervention

GHK-Cu

Comparator

Untreated inflamed larvae

Limitations

Zebrafish larvae. All three authors are employed by cosmetic-ingredient companies and the paper frames its conclusion as support for use as a functional cosmetic ingredient.