The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathways

Wen H, Zhao K, Luo X, Pu J, Li Y, Dou Y, He J, Nie X, Ke Y, Zhou W · Biogerontology

Extended lifespan and improved motility, pharyngeal pumping and defecation rhythm, with better oxidative and thermal stress resistance, less lipofuscin and lipid accumulation, preserved mitochondrial membrane potential and a shift toward mitochondrial fusion via DAF-16 and SKN-1.

Population

Caenorhabditis elegans

Intervention

GHK-Cu

Comparator

Untreated worms

Limitations

Invertebrate lifespan model. Nothing here speaks to mammalian tissue, dose or joint outcomes.