Endothelium-Dependent Nitric Oxide-Mediated Vasorelaxant Effects of BPC 157 in Human Internal Mammary Artery

Yildirim AK, Dastan AO, Demeli Ertus M, Ensarioglu M, Karabacak K, Pehlivanoglu B · Journal of Clinical Medicine

Concentration-dependent relaxation in both groups, significantly greater with endothelium intact (p<0.05); L-NAME attenuated the relaxation and abolished the endothelium advantage, with the curves converging at higher concentrations — the first functional BPC 157 data in human arterial tissue.

Population

Residual human internal mammary artery segments from 12 elective coronary bypass operations

Intervention

BPC 157 0.01–1 mg/mL, cumulative concentration-response, on phenylephrine-precontracted rings

Comparator

Endothelium-denuded rings, and rings pre-incubated with L-NAME

Limitations

Ex vivo human tissue, not a clinical outcome; concentrations are far above anything a systemic dose would produce; single centre, 12 donors.