Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification: A Randomized Clinical Trial

Vossen LM, de Leeuw PW, Schurgers LJ, et al. · JAMA Cardiology

Coronary calcium scores rose in both arms but less on MK-7: median 145 to 214 Agatston units on placebo against 135 to 184 on MK-7 over two years (P=0.02, robust to covariate adjustment), with plasma MK-7 rising from 0.50 to 6.56 ug/L and no significant adverse effects. The increase tracked non-calcified plaques becoming partly calcified, so what the finding means for plaque stability is unsettled.

Population

Patients with symptomatic coronary artery disease and a calcium score of 50-400 Agatston units (VitaK-CAC), 2 years

Intervention

MK-7 360 ug/day

Comparator

Placebo

Limitations

180 patients recruited over a decade with interruptions; calcium score is an imaging surrogate, not events; the authors themselves flag that slowing calcification of soft plaque may not be unambiguously good; registered as NCT01002157.