Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study

Biçer O, Adanir O, Güleryüz Y, et al. · Joint Diseases and Related Surgery

TB-500 significantly improved load to failure and histology scores; BPC-157 showed only non-significant numerical improvement; the combination added nothing over monotherapy.

Population

Rats with Achilles tendon injury

Intervention

BPC-157 10 µg/kg/day, TB-500 60 µg/kg/day, or both, i.p. for 4 weeks

Comparator

Saline

Limitations

Single small rodent study; a rare independent (non-Zagreb) test in which BPC-157 did not reach significance.