Peptide Supplements and Their Therapeutic Applications in Sports Medicine

Tewari K, Liu TP, Im C, Hamad C, Petrigliano F, Cheung EC, Kremen TJ Jr · The American Journal of Sports Medicine

Two-thirds of the identified publications were preclinical animal work; human studies were a handful, mostly without robust controls, and showed modest results at best. The authors conclude these peptides should not be recommended as a replacement or adjunct to orthopaedic standard of care.

Population

PRISMA scoping review of six marketed peptides — including TB-500 — against bone, fracture, muscle, tendon, ligament, meniscus and cartilage endpoints

Intervention

n/a

Comparator

n/a

Limitations

Scoping review, so no pooled effect estimates or formal risk-of-bias scoring; inherits the heterogeneity of a literature with almost no controlled human data.