BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats

Veljaca M, Lesch CA, Pllana R, Sanchez B, Chan K, Guglietta A · Journal of Pharmacology and Experimental Therapeutics

Intraperitoneal dosing reduced colonic necrosis and myeloperoxidase activity dose-dependently across five orders of magnitude; the intracolonic route at the same dose did nothing — an early, clean route-dependence result from a US pharmaceutical laboratory.

Population

Rats given intracolonic TNBS in 50% ethanol

Intervention

BPC-15 at 0.0001–10 nmol/kg intraperitoneally one hour before challenge, or 10 nmol/kg intracolonically

Comparator

Vehicle

Limitations

Parke-Davis (Warner-Lambert), an industrial sponsor evaluating a licensed candidate; a prophylactic model, not established colitis.