In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds

Maquart FX, Bellon G, Chaqour B, et al. · The Journal of Clinical Investigation

Concentration-dependent increases in dry weight, DNA, collagen, and glycosaminoglycan content of granulation tissue — the core in-vivo wound-healing result behind GHK-Cu's reputation.

Population

Rats with implanted wound chambers

Intervention

Repeated local GHK-Cu injection into wound chambers

Comparator

Vehicle-injected chambers

Limitations

Dermal wound model; no joint tissue involved.