Thymosin beta-4 expression is correlated with metastatic capacity of colorectal carcinomas

Yamamoto T, Gotoh M, Kitajima M, Hirohashi S · Biochemical and Biophysical Research Communications

The direction here is the reverse of the later literature: four non-metastatic lines expressed Tβ4 highly while three of four metastatic lines expressed it weakly, and the authors concluded that down-regulation correlates with metastatic capacity. Read from the title alone this record would be filed backwards.

Population

Paired metastatic and non-metastatic colorectal carcinoma cell lines and surgical specimens

Intervention

None — subtraction library and expression comparison

Comparator

Metastatic versus non-metastatic lines

Limitations

Small 1993 study with early methods and a single discordant surgical case; included because the oncology consensus is not unanimous and this is the clearest dissenting datum.