Effect of locally injected medications on healing of pad wounds in dogs

Swaim SF, Vaughn DM, Kincaid SA, Morrison NE, Murray SS, Woodhead MA, Hoffman CE, Wright JC, Kammerman JR · American Journal of Veterinary Research

Copper-tripeptide wounds carried more type I collagen than controls at day 6 and significantly more than all other wounds at day 14. The early planimetric healing-rate and hydroxyproline advantage belonged to the immunostimulant arm, not to the copper tripeptide.

Population

12 mature English Pointers with 6 × 8 mm full-thickness metatarsal and digital pad wounds

Intervention

Intralesional tripeptide-copper complex injected at days 0, 3 and 6

Comparator

Saline injection, and an immunostimulant arm

Limitations

Dermal footpad model. The collagen result and the healing-rate result point at different treatments, so the copper tripeptide's benefit here is compositional, not clinical.