Pentosan polysulfate-induced thrombocytopenia: a case diagnosed with an ELISA test used for heparin-induced thrombocytopenia

Gironell A, Altés A, Arboix A, Fontcuberta J, Muñoz C, Martí-Vilalta JL · Annals of Hematology

Severe thrombocytopenia and ischemic stroke during PPS treatment, with a strongly positive ELISA for heparin-induced-thrombocytopenia antibodies — evidence that PPS can trigger the same immune platelet-activation syndrome as heparin.

Population

One patient on PPS treatment

Intervention

Pentosan polysulfate (thrombosis-prophylaxis era use)

Comparator

None

Limitations

Single case within a small older case literature from PPS's European antithrombotic use; rare, but the failure mode is thrombosis, not just low platelets.