Morphological features of bone healing under the effect of collagen-graft-glycosaminoglycan copolymer supplemented with the tripeptide Gly-His-Lys

Pohunková H, Stehlík J, Váchal J, Cech O, Adam M · Biomaterials

Unfilled defects healed slowest, the gel without GHK healed substantially faster, and the complete GHK-containing gel healed fastest on radiography, NMR and histology. Osteogenic activity was visible at the trabecular bone-metal interface when the gel was used with cementless endoprostheses.

Population

Guinea pigs with artificially created femoral diaphyseal bone defects, and cementless endoprostheses

Intervention

Collagen-glycosaminoglycan gel supplemented with GHK, pefloxacin and hypersulphated glycosaminoglycan

Comparator

The same gel without GHK, and unfilled defects

Limitations

Diaphyseal bone, not an articular surface. Morphological scoring without stated animal numbers, randomisation or blinding; the gel is a four-component formulation.