Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats

Kalogjera L, Ries M, Baudoin T, Ferencic Z, Trotic R, Pegan B · European Archives of Oto-Rhino-Laryngology

Mast-cell infiltration was prevented at 1 hour at both doses, but only the 10 µg/kg dose significantly reduced polymorphonuclear infiltration, and a dose-dependent separation appeared only for that measure at 12 hours — one of the few records where the two standard doses did not behave identically.

Population

Wistar rats given intranasal capsaicin, assessed at 1, 3 and 12 hours

Intervention

BPC 157 10 µg/kg or 10 ng/kg i.p. as pretreatment

Comparator

Saline

Limitations

Small 1997 study scoring histology only; a Zagreb hospital ENT department, though outside the pharmacology group that produced most of the corpus.