Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats

Sikiric P, Seiwerth S, Grabarevic Z, et al. · Journal of Physiology, Paris

Attenuated development and course of adjuvant arthritis; the only joint-disease (rather than tendon/ligament) BPC-157 animal model published.

Population

Rats with Freund's adjuvant-induced arthritis

Intervention

BPC 157 10 µg or 10 ng/kg i.p., single dose or daily for 2 weeks to 1 year

Comparator

Saline

Limitations

Adjuvant arthritis models inflammatory arthritis, not osteoarthritis or cartilage defects; originating lab; 1997 methods.