Management of Osteoarthritis with Avocado/Soybean Unsaponifiables

Christiansen BA, Bhatti S, Goudarzi R, Emami S · Cartilage

Assembles the mechanism: ASU inhibits IL-1 and the metalloproteinases downstream of it, blocks the cartilage breakdown that follows, and stimulates aggrecan synthesis in chondrocyte culture — a coherent anabolic-plus-anticatabolic case, from work that is largely in vitro.

Population

In-vitro, animal and clinical studies of ASU in osteoarthritis

Intervention

Avocado/soybean unsaponifiables

Comparator

Varies

Limitations

Narrative review. Two authors were affiliated with a company marketing an ASU product at the time of writing, per the journal's disclosure.